Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats.

  title={Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats.},
  author={Robert G. Clark and J O Jansson and Olle Isaksson and Iain C. A. F. Robinson},
  journal={The Journal of endocrinology},
  volume={104 1},
Young hypophysectomized rats were maintained with chronic indwelling i.v. cannulae attached via swivels to a multichannel pumping system programmed to deliver GH in a continuous or pulsatile pattern for several days. Continuous i.v. infusions of human GH for 5 days produced dose-dependent increases in body weight and tail length, without increasing food intake. A comparison of GH infusions by the s.c. or i.v. route showed that the direct i.v. route was threefold more effective. Pulsatile i.v… CONTINUE READING
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