Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling.

@article{Katare2011IntravenousGT,
  title={Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling.},
  author={Rajesh G Katare and Andrea Caporali and Lorena Zentilin and Elisa Avolio and Graciela B. Sala-Newby and Atsuhiko Oikawa and Daniela Cesselli and Antonio Paolo Beltrami and Mauro Giacca and Costanza Emanueli and Paolo Madeddu},
  journal={Circulation research},
  year={2011},
  volume={108 10},
  pages={1238-51}
}
RATIONALE Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability. OBJECTIVE We investigated whether Pim-1 represents a novel mechanistic target for the cure of diabetic cardiomyopathy, a steadily increasing cause of nonischemic heart failure. METHODS AND RESULTS In streptozotocin-induced type 1 diabetic mice, Pim-1 protein levels declined during progression of… CONTINUE READING

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