Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

@article{Anthony2011IntravenousGS,
  title={Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway},
  author={Robert M. Anthony and Toshihiko Kobayashi and Fredrik Wermeling and Jeffrey V Ravetch},
  journal={Nature},
  year={2011},
  volume={475},
  pages={110-113}
}
High-dose intravenous immunoglobulin is a widely used therapeutic preparation of highly purified immunoglobulin G (IgG) antibodies. It is administered at high doses (1–2 grams per kilogram) for the suppression of autoantibody-triggered inflammation in a variety of clinical settings. This anti-inflammatory activity of intravenous immunoglobulin is triggered by a minor population of IgG crystallizable fragments (Fcs), with glycans terminating in α2,6 sialic acids (sFc) that target myeloid… CONTINUE READING
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shaping immune responses

  • T. B. Geijtenbeek, Gringhuis, S. I. Signalling through C-type lectin receptors
  • Nature Rev. Immunol. 9, 465–479
  • 2009

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