Intravenous flumazenil versus oxazepam tapering in the treatment of benzodiazepine withdrawal: a randomized, placebo‐controlled study

@article{Gerra2002IntravenousFV,
  title={Intravenous flumazenil versus oxazepam tapering in the treatment of benzodiazepine withdrawal: a randomized, placebo‐controlled study},
  author={Gilberto Gerra and Amir Zaimovic and F Giusti and Gabriele Moi and Claudette Brewer},
  journal={Addiction Biology},
  year={2002},
  volume={7}
}
Flumazenil (FLU), a benzodiazepine (BZD) partial agonist with a weak intrinsic activity, was previously found unable to precipitate withdrawal in tolerant subjects submitted to long‐lasting BZD treatment. The potential use of FLU to treat BZD withdrawal symptoms has also been evaluated tentatively in clinical studies. In the present experiment, FLU (treatment A) was compared with oxazepam tapering (treatment B) and placebo (treatment C) in the control of BZD withdrawal symptoms in three groups… 
Continuous Infusion of Flumazenil in the Management of Benzodiazepines Detoxification
TLDR
Elastomeric FLU infusion for BzD detoxification is a feasible administration device to maintain adequate, constant, and tolerated FLU concentrations for reducing BZD withdrawal symptoms.
High dose benzodiazepine dependence: Description of 29 patients treated with flumazenil infusion and stabilised with clonazepam
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TLDR
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TLDR
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TLDR
Evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to the authors' unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis to indicate that, when routinely associated with AEDs proplylaxis, low- dose slow sub cutaneous flumazerous infusion represents a safe procedure, with low risk of seizure occurrence.
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TLDR
To this day, the largest database of FLU detoxification was published by the Verona Detox group, showing how this treatment is safe, with very little side effects even in patients with significant medical comorbidities.
Switching from long-term benzodiazepine therapy to pregabalin in patients with generalized anxiety disorder: a double-blind, placebo-controlled trial
TLDR
The results on the anxiety and withdrawal severity measures suggest that switching to pregabalin may be a safe and effective method for discontinuing long-term benzodiazepine therapy.
Dependence on zolpidem: two case reports of detoxification with flumazenil infusion.
TLDR
This work describes two cases of zolpidem dependence that were detoxified by the use of flumazenil infusion and may represent an alternative to detoxification treatment by employing a tapering approach, or by replacement therapy with BDZs with a long half-life, particularly where patients are hard to treat or have low compliance to treatment.
Intravenous flumazenil infusion to treat benzodiazepine dependence should be performed in the inpatient clinical setting for high risk of seizure
TLDR
Flu-I appears to be a highly effective treatment resulting in withdrawal discomfort of lesser severity than any other treatment cessation currently available but, in the authors' opinion, FLU-I is not so safe as suggested by Hood et al.
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