Intravenous flumazenil versus oxazepam tapering in the treatment of benzodiazepine withdrawal: a randomized, placebo‐controlled study

@article{Gerra2002IntravenousFV,
  title={Intravenous flumazenil versus oxazepam tapering in the treatment of benzodiazepine withdrawal: a randomized, placebo‐controlled study},
  author={G. Gerra and A. Zaimovic and F. Giusti and G. Moi and C. Brewer},
  journal={Addiction Biology},
  year={2002},
  volume={7}
}
Flumazenil (FLU), a benzodiazepine (BZD) partial agonist with a weak intrinsic activity, was previously found unable to precipitate withdrawal in tolerant subjects submitted to long‐lasting BZD treatment. The potential use of FLU to treat BZD withdrawal symptoms has also been evaluated tentatively in clinical studies. In the present experiment, FLU (treatment A) was compared with oxazepam tapering (treatment B) and placebo (treatment C) in the control of BZD withdrawal symptoms in three groups… Expand
56 Citations
Benzodiazepine dependence and its treatment with low dose flumazenil
  • 65
Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases
  • 15
Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence
  • 8
Dependence on zolpidem: two case reports of detoxification with flumazenil infusion.
  • 33
Pharmacological uses of flumazenil in benzodiazepine use disorders: a systematic review of limited data
  • 1
  • Highly Influenced
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Intravenous flumazenil following prolonged exposure to lormetazepam in humans: lack of precipitated withdrawal
  • 12
A controlled study of flumazenil-precipitated withdrawal in chronic low-dose benzodiazepine users
  • 31
Feasibility of reversing benzodiazepine tolerance with flumazenil
  • 86
  • Highly Influential
Effectiveness of flumazenil (RO 15-1788) in the treatment of benzodiazepine withdrawal
  • 14
A pilot study of the effects of flumazenil on symptoms persisting after benzodiazepine withdrawal
  • 26
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users
  • 16
Pharmacology of flumazenil
  • 79
Intravenous flumazenil following acute and repeated exposure to lorazepam in healthy volunteers: antagonism and precipitated withdrawal.
  • 37
...
1
2
3
4
5
...