Intravenous diazepam and oral ethanol interaction.

@article{Sellers1980IntravenousDA,
  title={Intravenous diazepam and oral ethanol interaction.},
  author={Edward Sellers and Claudio A. Naranjo and Henry Giles and Richard C. Frecker and M Beeching},
  journal={Clinical pharmacology and therapeutics},
  year={1980},
  volume={28 5},
  pages={
          638-45
        }
}
  • Edward Sellers, Claudio A. Naranjo, +2 authors M Beeching
  • Published 1980
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • The mechanism of the interaction between ethanol and diazepam is not known. Six healthy male subjects (aged 21 to 32 yr) were randomly assigned in a balanced crossover study to each of two treatments, 28 days apart: (1) diazepam 10 mg intravenously over 20 min, preceded by 60 min with ethanol 0.7 gm/kg (diluted to 20% v/v) orally over 15 min and followed for 8 hr by ethanol 0.15 gm/kg/hr to maintain the blood alcohol concentrations between 800 to 1,000 mg/l; (2) diazepam 10 mg intravenously… CONTINUE READING

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