Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer.

@article{Pill2006IntravenousDO,
  title={Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer.},
  author={J-Y Pill{\'e} and Hong Li and Emmanuel Blot and J L Bertrand and L-L Pritchard and Paule Opolon and Andr{\'e}i Maksimenko and He Min Lu and J P Vannier and Jeannette Soria and C. Malvy and C. I. M. A. Arturo Soria},
  journal={Human gene therapy},
  year={2006},
  volume={17 10},
  pages={1019-26}
}
Overexpression of RhoA in cancer indicates a poor prognosis, because of increased tumor cell proliferation and invasion and tumor angiogenesis. We showed previously that anti-RhoA small interfering RNA (siRNA) inhibited aggressive breast cancer more effectively than conventional blockers of Rho-mediated signaling pathways. This study reports the efficacy and lack of toxicity of intravenously administered encapsulated anti-RhoA siRNA in chitosan-coated polyisohexylcyanoacrylate (PIHCA… CONTINUE READING

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