Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.

@article{Dow1999IntravenousCG,
  title={Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.},
  author={Steven Dow and Robyn E Elmslie and Lee G. Fradkin and Denny H. Liggitt and Timothy D. Heath and Andy P. Willson and Terry Potter},
  journal={Human gene therapy},
  year={1999},
  volume={10 18},
  pages={2961-72}
}
Local expression of cytokine genes by ex vivo transfection or intratumoral gene delivery can control the growth of cutaneous tumors. However, control of tumor metastases by conventional nonviral gene therapy approaches is more difficult. Intravenous injection of lipid-DNA complexes containing noncoding plasmid DNA can significantly inhibit the growth of early metastatic lung tumors. Therefore, we hypothesized that delivery of a cytokine gene by lipid-plasmid DNA complexes could induce even… CONTINUE READING

From This Paper

Topics from this paper.
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…