Intravenous cocaine challenges during desipramine maintenance.

@article{Kosten1992IntravenousCC,
  title={Intravenous cocaine challenges during desipramine maintenance.},
  author={Thomas R. Kosten and Frank H. Gawin and David G. Silverman and John Fleming and Montana Compton and Peter I. Jatlow and Robert Byck},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={1992},
  volume={7 3},
  pages={
          169-76
        }
}
Intravenous challenges with placebo and cocaine doses ranging from 0.125 to 0.5 mg/kg were administered to five subjects using a within subjects design during placebo and active desipramine (DMI) maintenance at a fixed dose of 150 mg daily for at least 10 days. The "high" reported after cocaine infusion was not altered by DMI, but "desire for cocaine" after a single dose was attenuated. Together with the results of clinical trials of DMI for cocaine abuse, these laboratory results suggest that… CONTINUE READING

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