Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial.

@article{Bigal2002IntravenousCI,
  title={Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial.},
  author={M. Bigal and C. Bordini and J. Speciali},
  journal={The Journal of emergency medicine},
  year={2002},
  volume={23 2},
  pages={
          141-8
        }
}
The aim of this study is to assess, in a double blind randomized clinical trial, the effect of chlorpromazine (CPZ) on the pain and associated symptoms in patients with migraine. Sixty patients with migraine with aura and 68 patients with migraine without aura were assigned at random to receive IV 0.1 mg/Kg CPZ or placebo. We assessed pain intensity, nausea, photophobia, and phonophobia at baseline, 30 min, and 60 min post-IV administration. End-point efficacy at 60 min was used to calculate… Expand
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