Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat.

@article{Chen2003IntravenousBM,
  title={Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat.},
  author={Jieli Chen and Yi Li and Mark Katakowski and Xiaoguang Chen and Lei Wang and Dunyue Lu and Mei Lu and Subhash C. Gautam and Michael Chopp},
  journal={Journal of neuroscience research},
  year={2003},
  volume={73 6},
  pages={778-86}
}
The present study investigates the induction of neurogenesis, reduction of apoptosis, and promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by which treatment of stroke with bone marrow stromal cells (MSCs) improves neurological functional recovery. Additionally, for the first time, we treated cerebral ischemia in female rats with intraveneous administration of MSCs. Female rats were subjected to 2 hr of middle cerebral artery occlusion (MCAo), followed by an… CONTINUE READING
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