Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo.

@article{Kirkby2007IntravenousBP,
  title={Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo.},
  author={Kristin A Kirkby and Chris Baylis and Anupam Agarwal and Byron P. Croker and L. Archer and Christopher A. Adin},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 2},
  pages={F888-94}
}
Exogenous bilirubin (BR) substitutes for the protective effects of heme oxygenase (HO) in several organ systems. Our objective was to investigate the effects of exogenous BR in an in vivo model of ischemia-reperfusion injury (IRI) in the rat kidney. Four groups of male Sprague-Dawley rats were anesthetized using isoflurane in oxygen and treated with 1) 5 mg/kg intravenous (iv) BR, 1 h before ischemia and 6-h reperfusion; 2) vehicle 1 h before ischemia and 6-h reperfusion; 3) 20 mg/kg iv BR, 1 h… CONTINUE READING

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