• DOI:10.1016/0002-8703(86)90047-5
Corpus ID: 32621220

Intravenous and oral lorcainide: assessment of central nervous system toxicity and antiarrhythmic efficacy.

@article{Vlay1986IntravenousAO,
  title={Intravenous and oral lorcainide: assessment of central nervous system toxicity and antiarrhythmic efficacy.},
  author={S. Vlay and G. Mallis},
  journal={American heart journal},
  year={1986},
  volume={111 3},
  pages={
          452-5
        }
}

S. Vlay, G. Mallis

Published 1986

Medicine

American heart journal

Twenty-eight subjects underwent evaluation of drug toxicity and antiarrhythmic efficacy with oral and intravenous lorcainide. Lorcainide, a new type 1C antiarrhythmic drug, has an active metabolite, norlorcainide, which accumulates after oral but not significantly after intravenous administration. Group 1 consisted of 14 subjects who received intravenous lorcainide with an initial bolus of 2 mg/kg at a rate of 2 mg/min followed by 0.14 mg/min or 200 mg/24 hours. The lorcainide level after bolus… CONTINUE READING

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