Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial.

@article{Winston2003IntravenousAO,
  title={Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial.},
  author={Drew J. Winston and Richard T Maziarz and Pranatharthi Chandrasekar and Hillard M Lazarus and Mitchell H. Goldman and Jeffrey L. Blumer and Gerhard J Leitz and Mary C. Territo},
  journal={Annals of internal medicine},
  year={2003},
  volume={138 9},
  pages={705-13}
}
Context Fungal infections after allogeneic hematopoietic stem-cell transplantation are a serious problem. Current prophylactic regimens are limited by toxicity and the emergence of resistant infections. Contribution This open-label randomized trial of 140 patients undergoing stem-cell transplantation found that prophylaxis with itraconazole for 100 days after transplantation prevented more invasive fungal infections than did prophylaxis with fluconazole (absolute difference, 16 percentage… CONTINUE READING

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