Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.

@article{Spruit2000IntravenousAI,
  title={Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.},
  author={H. Spruit and J. Langenberg and H. Trap and H. J. van der Wiel and R. Helmich and H. V. van Helden and H. Benschop},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={169 3},
  pages={
          249-54
        }
}
We report the first toxicokinetic studies of (+/-)-sarin. The toxicokinetics of the stereoisomers of this nerve agent were studied in anesthetized, atropinized, and restrained guinea pigs after intravenous bolus administration of a dose corresponding to 0.8 LD50 and after nose-only exposure to vapor concentrations yielding 0.4 and 0.8 LCt50 in an 8-min exposure time. During exposure the respiratory minute volume and frequency were monitored. Blood samples were taken for gas chromatographic… Expand
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Sarin: health effects, metabolism, and methods of analysis.
  • A. Abu-Qare, M. Abou‐Donia
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2002
TLDR
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