Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits.

@article{Cichon1999IntravenousAO,
  title={Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits.},
  author={Guenter Cichon and Hartmut H-J Schmidt and Tahar Benhidjeb and Peter L{\"o}ser and Sabine Ziemer and Rainer Haas and Niels Grewe and Frank Schnieders and Joerg Heeren and Michael P. Manns and Peter M. Schlag and Merav Strauss},
  journal={The journal of gene medicine},
  year={1999},
  volume={1 5},
  pages={360-71}
}
BACKGROUND Recombinant adenoviruses are highly efficient gene transfer vehicles but their administration to mammals is accompanied by a strong inflammatory response. The present study reports additional side effects observed during adenoviral gene transfer studies in rabbits. METHODS Hematological and serological parameters, the course of viremia and the organ distribution were analyzed after in vivo administration of E1-deleted adenoviruses in rabbits. RESULTS The systemic administration… CONTINUE READING

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