Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage.

@article{Santoro1986IntravenousAO,
  title={Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage.},
  author={Nanette F. Santoro and Margaret E. Wierman and Marco Filicori and Joanne Waldstreicher and William Francis Crowley},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={62 1},
  pages={109-16}
}
Eighteen women with well characterized hypothalamic amenorrhea underwent 30 cycles of pulsatile GnRH treatment in an effort to examine the role of GnRH dosage in pituitary and ovarian responses. GnRH was administered iv at 2 doses (25 and 100 ng/kg bolus) at a physiological range of frequencies (90 and 60 min) in the follicular phase of the induced cycles. After demonstration of ovulation by ultrasound and clinical parameters, the frequency of GnRH administration was progressively slowed from… CONTINUE READING