Intravenous administration of diphenhydramine reduces histamine-induced vasodilator effects in the retina and choroid.

Abstract

PURPOSE Intravenous administration of histamine causes an increase in choroidal blood flow (ChBF) and retinal vessel diameters in healthy subjects. The receptor mediating this response has not yet been identified. The present study was undertaken to clarify whether H1 receptor blockade with diphenhydramine affects the hemodynamic response of histamine in… (More)

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