Intravenous administration of L-arginine inhibits angiotensin-converting enzyme in humans.

  title={Intravenous administration of L-arginine inhibits angiotensin-converting enzyme in humans.},
  author={Yukihiro Higashi and Tetsuya Oshima and Norihisa Ono and Hiroyuki Hiraga and Manabu Yoshimura and Masazumi Watanabe and Hideo Matsuura and Masayuki Kambe and Goro Kajiyama},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={80 7},
The iv administration of L-arginine, a precursor of endothelium-derived relaxing factor/nitric oxide, is known to decrease blood pressure in humans by its direct vasodilatory effects. The purpose of the present study was to determine whether L-arginine infusion modifies the renin-angiotensin (Ang)-aldosterone system as well as blood pressure and renal hemodynamics. L-Arginine and saline vehicle were iv administered to 10 healthy male subjects in random order on different days. L-Arginine… CONTINUE READING

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