Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.

  title={Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.},
  author={L. Prescott and R. Illingworth and J. Critchley and A. Proudfoot},
  journal={British Medical Journal},
  pages={46 - 47}
One hundred cases of severe paracetamol poisoning were treated with intravenous N-acetylcysteine (acetyl-cysteine). There was virtually complete protection against liver damage in 40 patients treated within eight hours after ingestion (mean maximum serum alanine transaminase activity 27 IU/1). Only one out of 62 patients treated within 10 hours developed severe liver damage compared with 33 out of 57 patients (58%) studied retrospectively who received supportive treatment alone. Early treatment… Expand
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  • W. Waring
  • Medicine
  • Therapeutic advances in drug safety
  • 2012
Changing the Management of Paracetamol Poisoning.