Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling

@inproceedings{RajeshKatare2011IntravenousGT,
  title={Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling},
  author={RajeshKatare and AndreaCaporali and LorenaZentilin and ElisaAvolio and GracielaSala-Newby and AtsuhikoOikawa and DanielaCesselli and Antonio PaoloBeltrami and MauroGiacca and CostanzaEmanueli and PaoloMadeddu},
  year={2011}
}
Rationale:Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability. Objective:We investigated whether Pim-1 represents a novel mechanistic target for the cure of diabetic cardiomyopathy, a steadily increasing cause of nonischemic heart failure. Methods and Results:In streptozotocin-induced type 1 diabetic mice, Pim-1 protein levels declined during progression of cardiomyopathy… CONTINUE READING

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