Intravenous Esomeprazole

@article{Keating2012IntravenousE,
  title={Intravenous Esomeprazole},
  author={Gillian M. Keating},
  journal={PharmacoEconomics},
  year={2012},
  volume={29},
  pages={535-543}
}
  • G. Keating
  • Published 1 June 2011
  • Medicine
  • PharmacoEconomics
Intravenous esomeprazole (Nexium®) is approved in Europe for the prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers.In a pivotal clinical trial, patients with peptic ulcer bleeding and high-risk stigmata who received intravenous esomeprazole for 72 hours following endoscopic haemostatic therapy were significantly less likely than those receiving intravenous placebo to experience recurrent peptic ulcer bleeding at days 3, 7 and 30. In addition… Expand

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TLDR
Esomeprazole, given as a continuous high- dose intravenous infusion followed by an oral regimen after successful endoscopic therapy for PUB, was well tolerated, with no apparent safety concerns from either the high-dose intravenous treatment or oral phases. Expand
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TLDR
High-dose intravenous esomeprazole given after successful endoscopic therapy to patients with high-risk peptic ulcer bleeding reduced recurrent bleeding at 72 hours and had sustained clinical benefits for up to 30 days. Expand
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TLDR
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TLDR
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