Intravenous Chloroprocaine Attenuates Hemodynamic Changes Associated with Direct Laryngoscopy and Tracheal Intubation

@article{Durrani2000IntravenousCA,
  title={Intravenous Chloroprocaine Attenuates Hemodynamic Changes Associated with Direct Laryngoscopy and Tracheal Intubation},
  author={Mehmood A Durrani and John A. Barwise and R. F. Johnson and J. Reddy Kambam and Piotr K. Janicki},
  journal={Anesthesia \& Analgesia},
  year={2000},
  volume={90},
  pages={1208–1212}
}
We compared the effects of an IV administration of chloroprocaine and lidocaine on circulatory responses associated with endotracheal intubation. Thirty patients were randomly allocated to receive normal saline (placebo), lidocaine (1.5 mg/kg), or preservative-free chloroprocaine (4.5 mg/kg) 45 s before endotracheal intubation. Blood pressures and heart rate and rhythm were recorded before laryngoscopy and at 0.5, 1, 1.5, 2, 3, and 5 min after intubation. Blood samples were analyzed for… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
The effect of plain 0.5% 2–chloroprocaine on venous endothelium after intravenous regional anaesthesia in the rabbit
TLDR
It is concluded that additive–free 2–chloroprocaine caused damage to the venous endothelium in rabbits when used for IVRA. Expand
Comparison of 2‐chloroprocaine and prilocaine for intravenous regional anaesthesia of the arm: a clinical study
TLDR
Clinically, local anaesthetic properties of 0.5% 2‐chloroprocaine and prilocaine were similar, but there were more side‐effects with the former drug. Expand
2‐Chloroprocaine and Bupivacaine Are Unreliable Indicators of Intravascular Injection in the Premedicated Patient
TLDR
While 90 mg 2‐CP or 25 mg B may be reliable alternatives to epinephrine test doses in unpremedicated subjects, they are unreliable indicators of intravascular injection in the premedicated patient. Expand
Detection of Intravascular Epidural Catheters Using 2‐Chloroprocaine: Influence of Local Anesthetic Dose and Nalbuphine Premedication
TLDR
It is suggested that patients who receive nalbuphine for analgesia prior to epidural placement will be more likely to report symptoms after receiving intravenous 2‐chloroprocaine during epidural test dosing. Expand
Intravenous regional anaesthesia with 0.5% prilocaine or 0.5% chloroprocaine
Ten healthy male volunteers received intravenous regional anaesthesia of the upper limb on two separate occasions using 40 ml of 0.5% prilocaine or 40 ml plain 0.5% chloroprocaine by randomExpand
Epidural test dose: lidocaine 100 mg, not chloroprocaine, is a symptomatic marker of iv injection in labouring parturients
TLDR
It is concluded that lidocaine 100 mg is a sensitive marker of intravascular injection in labouring parturients, and that tinnitus+taste is the most reliable indicator of intravenous injection. Expand
Comparison of acute central nervous system and cardiovascular toxicity of 2‐chloroprocaine and prilocaine in the rat
TLDR
It is concluded that prilocaine is slightly more toxic than 2‐chloroprocaine in the rat, but that both local anaesthetics have a wide margin of safety. Expand
Metabolism and measurement of chloroprocaine, an ester-type local anesthetic.
TLDR
Data was obtained showing that chloroprocaine is hydrolyzed rapidly by plasma cholinesterases, and no unchanged drug could be detected in any blood samples obtained from volunteers who received chloropropaine by intravenous infusion or from obstetric patients who had epidural anesthesia during labor and delivery. Expand
Intra-arterial chloroprocaine for the control of pain associated with partial splenic embolization.
TLDR
A splenic embolization was successfully undertaken to ablate partially the splenic parenchyma allowing increased doses of cyclophosphamide immunosuppressive therapy to be used in the management of the renal transplant rejection. Expand
A brief psychotic reaction during the administration of intravenous 2-chloroprocaine for the treatment of chronic pain
TLDR
Lidocaine and 2-chloroprocaine administered intravenously have gained popularity in the treatment of chronic pain and it has been conjectured that intravenous local anesthetics reduce pain both by peripheral and central effects. Expand
...
1
2
3
...