Intravenous Cereport (RMP-7) Enhances Delivery of Hydrophilic Chemotherapeutics and Increases Survival in Rats with Metastatic Tumors in the Brain

@article{Emerich2000IntravenousC,
  title={Intravenous Cereport (RMP-7) Enhances Delivery of Hydrophilic Chemotherapeutics and Increases Survival in Rats with Metastatic Tumors in the Brain},
  author={Dwaine F. Emerich and Reginald L. Dean and Joanne Marsh and Melissa Pink and Denise Lafreniere and Pamela Snodgrass and Raymond T. Bartus},
  journal={Pharmaceutical Research},
  year={2000},
  volume={17},
  pages={1212-1219}
}
Purpose. The following experiments determined whether intravenous infusions of Cereport enhance delivery of chemotherapeutics and prolong survival in rats with metastatic tumors in the brain. Methods. Autoradiography and scintillation were used to examine uptake of the lipophilic (paclitaxel and carmustine) and the hydrophilic (carboplatin) chemotherapeutic agents, as well as the large hydrophilic marker, 70 kDa dextran. Cereport was also tested in combination with the chemotherapeutic drugs… CONTINUE READING