• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2015
  • DOI:10.1002/jps.24482

Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status.

@article{Zhou2015IntravenousAO,
  title={Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status.},
  author={Jie Zhou and Lisa D Coles and Reena V Kartha and Nardina Nash and Usha Mishra and Troy C Lund and James C Cloyd},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 8},
  pages={
          2619-26
        }
}
There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The purpose of this study was to characterize the biosynthesis of NAC to GSH using a novel stable isotope-labeled technique, and investigate the pharmacodynamics of NAC in vivo. Female wild-type mice were given a single intravenous bolus dose of 150 mg kg(-1) stable-labeled NAC. Plasma, red blood cells (RBC), and brain tissues… CONTINUE READING
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Interaction of N-acetylcysteine and cysteine in human plasma.