Intravenous Administration of Human Bone Marrow Stromal Cells Induces Angiogenesis in the Ischemic Boundary Zone After Stroke in Rats

@article{Chen2003IntravenousAO,
  title={Intravenous Administration of Human Bone Marrow Stromal Cells Induces Angiogenesis in the Ischemic Boundary Zone After Stroke in Rats},
  author={J. Chen and Z. Zhang and Y. Li and L. Wang and Y. X. Xu and S. Gautam and Mei Lu and Zhenping Zhu and M. Chopp},
  journal={Circulation Research: Journal of the American Heart Association},
  year={2003},
  volume={92},
  pages={692-699}
}
  • J. Chen, Z. Zhang, +6 authors M. Chopp
  • Published 2003
  • Medicine
  • Circulation Research: Journal of the American Heart Association
Abstract— We tested the hypothesis that intravenous infusion of human bone marrow stromal cells (hMSCs) promotes vascular endothelial growth factor (VEGF) secretion, VEGF receptor 2 (VEGFR2) expression and angiogenesis in the ischemic boundary zone (IBZ) after stroke. hMSCs (1×106) were intravenously injected into rats 24 hours after middle cerebral artery occlusion (MCAo). Laser scanning confocal microscopy (LSCM), immunohistochemistry and ELISA were performed to assay angiogenesis and levels… Expand
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