Intravenous Abuse of Propylhexedrine (Benzedrex®) and the Risk of Brainstem Dysfunction in Young Adults

@article{Fornazzari1986IntravenousAO,
  title={Intravenous Abuse of Propylhexedrine (Benzedrex{\textregistered}) and the Risk of Brainstem Dysfunction in Young Adults},
  author={Luis R. Fornazzari and Peter L. Carlen and Bhushan M. Kapur},
  journal={Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques},
  year={1986},
  volume={13},
  pages={337 - 339}
}
  • L. Fornazzari, P. Carlen, B. Kapur
  • Published 1 November 1986
  • Medicine, Psychology
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
ABSTRACT: In 1949, amphetamine sulfate was replaced by propylhexedrine in the nasal decongestant agent Benzedrex® because of psychosis, sudden death, and widespread abuse. Propylhexedrine is not without risks, and reported cases of psychosis, myocardial infarction, pulmonary vascular disease and pulmonary hypertension, and sudden death are well documented in the medical literature. We are reporting 2 cases of definite brainstem dysfunction and 5 cases of transient diplopia secondary to IV abuse… 

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References

SHOWING 1-10 OF 21 REFERENCES

COLLAPSE WITH DEATH FOLLOWING THE USE OF AMPHETAMINE SULFATE

During the past few years the use of amphetamine sulfate as a stimulating drug has become increasingly widespread, and the public is becoming familiar with it, and its use among students is probably more common than one would think.

Oral use of stimulants obtained from inhalers.

Amphetamine ("benzedrine") has become a popular drug among the laity as evidenced by its mention in songs, magazines and commercial advertisements. The song "Who Put the Benzedrine in Mrs. Murphy's

Cerebellar, cortical and functional impairment in toluene abusers

After 2 weeks of abstinence, several liver function tests which were abnormal on admission had recovered, but only minimal changes in the CNS symptoms were observed, and the duration of abuse was only weakly correlated with neurological scores.

Psychosis Due to Nasal Decongestant Abuse

  • D. McIntyre
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1976
Until the day when either grid or clinical judgement provides us with an argument from which the authors can derive a way of helping the so-called thought disordered schizophrenic, neither grid nor clinical judge meat has †̃¿ clinical utility'.

Intracerebral hemorrhage and oral amphetamine.

Four patients suffered intracerebral hemorrhages following the oral or nasal use of amphetamine or related compounds. Two of these patients had abnormal-appearing cerebral blood vessels on

Acute Hallucinosis as a Complication of Addiction to Amphetamine Sulfate

Two new drugs have been developed for the treatment of chronic alcoholism and narcolepsy using Benzedrine sulfate and its analogs, which have shown promise in treating both alcoholism and depression.

Cerebral vascular changes secondary to amphetamine abuse in the experimental animal.

All 5 animals at necropsy demonstrated extensive brain damage and there were focal areas of ischemia and infarction and generalized areas of cerebral edema and ischemic nerve cell changes.

Oral overdose of propylhexedrine.

We present a case of an oral overdose of cotton pledgets saturated with propylhexedrine, the active chemical in Benzedrex ® inhalers. The tissue levels are included for reference purposes.

Amount of therapist contact and outcome in a multidimensional depression treatment program

The effectiveness of this multidimensional program of behavioral management, cognitive restructuring, and assertiveness training was supported, but its efficacy was not systematically influenced by amount of therapist contact.