Intravascular lymphomatosis and intracerebral haemorrhage


Intravascular lymphomatosis (IVL) is a rare, malignant B- or T-cell lymphoma with remarkable affinity for the endothelial cells of small vessels, particularly within the skin and central nervous system. It is a disease that mimics several neurological disorders, particularly those of cerebrovascular ischemic origin. The prognosis is generally poor, with a rapidly fatal outcome. As a result the diagnosis is often made at post-mortem. We report a rare case of a 73-year-old patient with IVL complicated by intracerebral haemorrhage. In literature two cases of systemic IVL complicated by intracerebral haemorrhage have been reported, but they presented initially with a disseminated intravascular coagulation (DIC). This is the first case of brain IVL complicated by intracerebral haemorrhage not associated to DIC. Increasing awareness of this disease as a differential diagnosis to a common clinical presentation may lead to more opportunities to evaluate new diagnostic and treatment approaches.

DOI: 10.1007/s10072-010-0284-7

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@article{Passarin2010IntravascularLA, title={Intravascular lymphomatosis and intracerebral haemorrhage}, author={Maria Grazia Passarin and Patrick Yung Chih Wen and Emanuela Vattemi and Ebba C. Buffone and Claudio Ghimenton and Lamberto Bontempini and Sarah Ottaviani and Anna Maria Musso and Rebecca Pedersini}, journal={Neurological Sciences}, year={2010}, volume={31}, pages={793-797} }