Intravascular immunity: the host–pathogen encounter in blood vessels

@article{Hickey2009IntravascularIT,
  title={Intravascular immunity: the host–pathogen encounter in blood vessels},
  author={Michael J. Hickey and Paul Kubes},
  journal={Nature Reviews Immunology},
  year={2009},
  volume={9},
  pages={364-375}
}
The immune system provides an essential defence against invading pathogens. However, bacteria have evolved numerous strategies to overcome this defence, many of which facilitate systemic dissemination of the pathogen. Nevertheless, the host has evolved many mechanisms to detect and protect against pathogens in the vasculature. Recent studies using new imaging approaches and new mouse models are revealing previously unappreciated functions of this intravascular aspect of the immune system. In… Expand
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