Intravascular delivery of hyperpolarized129Xenon forin vivo MRI

  title={Intravascular delivery of hyperpolarized129Xenon forin vivo MRI},
  author={Jan Wolber and Ian John Rowland and Martin O. Leach and Angelo Bifone},
  journal={Applied Magnetic Resonance},
The nuclear polarization of129Xe and3He can be enhanced by several orders of magnitude by using optical pumping techniques, thus allowing NMR detection of xenon and helium in very low concentrations. The benefits of optically enhanced magnetic resonance (MR) are already exploited in MR imaging of the lungs using optically polarized3He. The high solubility of xenon in blood and lipids suggests a variety ofin vivo MR applications, for instance perfusion measurements or functional MR studies. This… Expand
Medical imaging with laser-polarized noble gases
The field of medical imaging with polarized rare gases, just five years old, has brought optical scientists together with medical researchers to perfect techniques and pursue new opportunities forExpand
Hyperpolarized xenon relaxation times in perfluorocarbon emulsion and plasma mixtures
Hyperpolarized xenon (Hyp-/sup 129/Xe) has great potential in perfusion, blood flow and functional investigations of organs beyond the lungs. Injection of xenon in a dissolved carrier would be theExpand
Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms.
The sensitivity of conventional nuclear magnetic resonance (NMR) techniques is fundamentally limited by the ordinarily low spin polarization achievable in even the strongest NMR magnets. However, byExpand
Non-traditional applications of NMR tomography
Applications of NMR imaging to studies of chemical reactions including polymerisation reactions and the Belousov-Zhabotinsky oscillating reaction are considered. Publications concerning applicationsExpand
In vivo 129Xe NMR in rat brain during intra-arterial injection of hyperpolarized 129Xe dissolved in a lipid emulsion.
Kinetics of hyperpolarized 129Xe administered to anaesthetized rats by manual injections into the carotid revealed a rapid intensity increase, followed by a plateau and then a decrease over 5 s, attributed to combined influences of the T1 relaxation of the tracer, of radiofrequency sampling, and of thetracer perfusion rate in rat brain. Expand
Magnetic resonance spectroscopy (MRS) in the investigation of cancer at The Royal Marsden Hospital and The Institute of Cancer Research.
  • M. Leach
  • Medicine
  • Physics in medicine and biology
  • 2006
Developments in magnetic resonance spectroscopy (MRS) at The Royal Marsden Hospital and The Institute of Cancer Research are reviewed in the context of preceding developments in nuclear magneticExpand
129Xe NMR in study of tissues and plants
The high sensitivity of the129Xe nuclear magnetic resonance (NMR) chemical shift to the environment was used for characterization of biological tissues and plants. The xenon gas was dissolved underExpand


In vivo NMR and MRI using injection delivery of laser-polarized xenon.
  • B. Goodson, Y. Song, +6 authors A. Pines
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
Preliminary results from the application of a polarized xenon injection technique for in vivo 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized Xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold. Expand
Determinants of tissue delivery for 129Xe magnetic resonance in humans
The resulting model predicts the 129Xe magnetization in different tissues as a function of the time from the start of inhalation, the tissue perfusion rate and partition coefficient for xenon, and the relevant T1 decay times, and its expected signal‐to‐noise ratio (SNR) is approximately 2% of the equivalent SNR from proton MR. Expand
Enhancement of Solution NMR and MRI with Laser-Polarized Xenon
Optical pumping with laser light can be used to polarize the nuclear spins of gaseous xenon-129. When hyperpolarized xenon-129 is dissolved in liquids, a time-dependent departure of the proton spinExpand
NMR of laser-polarized xenon in human blood.
  • A. Bifone, Y. Song, +6 authors A. Pines
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
The first observation of the time-resolved process of xenon penetrating the red blood cells in fresh human blood is made using the described method, which is an efficient method for the introduction of laser-polarized xenon into systems of biological and medical interest for the purpose of obtaining highly enhanced NMR/MRI signals. Expand
Biological magnetic resonance imaging using laser-polarized 129Xe
It is shown that 129Xe gas can be used for high-resolution MRI when the nuclear-spin polarization of the atoms is increased by laser optical pumping and spin exchange, which produces hyperpolarized 129xe, in which the magnetization is enhanced by a factor of about 105. Expand
Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He
It is demonstrated that hyper‐polarized 3He gas can be applied to nuclear magnetic resonance imaging of organs with air‐filled spaces in humans and for pulmonary ventilation studies. Expand
Measurement of 129Xe T1 in Blood to Explore the Feasibility of Hyperpolarized 129Xe MRI
These relaxation times, though shorter than expected, are comparable to the transport time of blood, and are long enough to encourage use of hyperpolarized xenon for MRI studies in tissues, in addition to lung. Expand
Hyperpolarized 129Xe MR imaging of the oral cavity.
The first hyperpolarized xenon MRI (HypX-MRI) offers a new tion trapping that promises temporal and spatial resolutions comparable to conventional Hyperpolarization of Xe is achieved through spin-exchange collisions with optically pumped Rb vapor. Expand
Brain MRI with laser‐polarized 129xe
It is established that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged and increases in polarization and delivered volume of 129Xe will allow clinical measurements of regional cerebral blood flow. Expand
MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human results
The results suggest the feasibility of dissolved‐phase imaging of both the chest and brain with a resolution similar to that obtained with the gas‐phase images. Expand