Intravascular bone marrow accumulation in persistent polyclonal lymphocytosis: a misleading feature for B-cell neoplasm

@article{Feugier2004IntravascularBM,
  title={Intravascular bone marrow accumulation in persistent polyclonal lymphocytosis: a misleading feature for B-cell neoplasm},
  author={Pierre Feugier and Anne Kennel de March and J-F Lesesve and Nathalie Monhoven and V{\'e}ronique Dorvaux and Françoise Braun and Marie Jos{\'e} Gr{\'e}goire and Philippe Jonveaux and Pierre Lederlin and Marie Christine B{\'e}n{\'e} and Eric Labouyrie},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={1087-1096}
}
Persistent polyclonal B-cell lymphocytosis is usually reported in young smoking women. Whether this syndrome represents a premalignant or benign disease remains unclear. Indeed, because of the association of Bcl-2/IgH rearrangement and cytogenetic abnormalities, such cases may be misdiagnosed as the leukemic phase of a non-Hodgkin's lymphoma. We report eight new cases of persistent polyclonal B-cell lymphocytosis, which displayed a misleading bone marrow histological pattern, that is… CONTINUE READING

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