Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.

@article{Hiltunen2000IntravascularAV,
  title={Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.},
  author={Mikko Hiltunen and Marjo Laitinen and Mikko Petri Turunen and Martin Jeltsch and Juha Hartikainen and Tuomas T. Rissanen and Jarkko Laukkanen and Mari Niemi and Maija Kossila and Tomi P H{\"a}kkinen and Antti Kivel{\"a} and Berndt C. Enholm and Hannu K. Mansukoski and A M Turunen and Kali Alitalo and Seppo Yl{\"a}-Herttuala},
  journal={Circulation},
  year={2000},
  volume={102 18},
  pages={2262-8}
}
BACKGROUND Gene transfer to the vessel wall may provide new possibilities for the treatment of vascular disorders, such as postangioplasty restenosis. In this study, we analyzed the effects of adenovirus-mediated vascular endothelial growth factor (VEGF)-C gene transfer on neointima formation after endothelial denudation in rabbits. For comparison, a second group was treated with VEGF-A adenovirus and a third group with lacZ adenovirus. Clinical-grade adenoviruses were used for the study… CONTINUE READING

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Vascular endothelial growth factor (VEGF) and its receptors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1999

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