Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans.

@article{Yegutkin2007IntravascularAA,
  title={Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans.},
  author={Gennady G Yegutkin and Sergei S. Samburski and Stefan P Mortensen and Sirpa Jalkanen and Jos{\'e} Gonz{\'a}lez-Alonso},
  journal={The Journal of physiology},
  year={2007},
  volume={579 Pt 2},
  pages={553-64}
}
Extracellular ATP and ADP trigger vasodilatatory and prothrombotic signalling events in the vasculature. Here, we tested the hypothesis that nucleotide turnover is activated in the bloodstream of exercising humans thus contributing to the enhanced platelet reactivity and haemostasis. Right atrial, arterial and venous blood samples were collected from endurance-trained athletes at rest, during submaximal and maximal cycle ergometer exercise, and after early recovery. ATP-specific bioluminescent… CONTINUE READING