Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses

@inproceedings{McKay2017IntravaginalIU,
  title={Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses},
  author={Paul F McKay and Jamie F S Mann and Aditya Pattani and Vicky L. Kett and Yoann Aldon and Deborah F. L. King and R. Karl Malcolm and Robin J Shattock},
  booktitle={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017}
}
The generation of effective levels of antigen-specific immunity at the mucosal sites of pathogen entry is a key goal for vaccinologists. We explored topical vaginal application as an approach to initiate local antigen-specific immunity, enhance previously existing systemic immunity or re-target responses to the mucosae. To deliver a protein vaccine… CONTINUE READING