Intrauterine programming of fetal islet gene expression in rats—effects of maternal protein restriction during gestation revealed by proteome analysis

@article{Sparre2003IntrauterinePO,
  title={Intrauterine programming of fetal islet gene expression in rats—effects of maternal protein restriction during gestation revealed by proteome analysis},
  author={Thomas Sparre and Brigitte M Reusens and Hichem Cherif and Martin R Larsen and Peter Roepstorff and Stephen John Fey and Peter Mose Larsen and Claude A Remacle and Prof. J. Nerup},
  journal={Diabetologia},
  year={2003},
  volume={46},
  pages={1497-1511}
}
Fetal undernutrition can result in intrauterine growth restriction and increased incidence of Type 2 diabetes mellitus. Intrauterine malnutrition in form of an isocaloric low-protein diet given to female rats throughout gestation decreases islet-cell proliferation, islet size and pancreatic insulin content, while increasing the apoptotic rate and sensitivity to nitrogen oxide and interleukin-1β. Hence, the influence of a low-protein diet on the development of beta-cells and islets could also be… CONTINUE READING