Intrauterine hypoxia upregulates proinflammatory cytokines and matrix metalloproteinases in fetal guinea pig hearts.

@article{Oh2008IntrauterineHU,
  title={Intrauterine hypoxia upregulates proinflammatory cytokines and matrix metalloproteinases in fetal guinea pig hearts.},
  author={Chien Oh and Yafeng Dong and Hongshan Liu and Loren P. Thompson},
  journal={American journal of obstetrics and gynecology},
  year={2008},
  volume={199 1},
  pages={78.e1-6}
}
OBJECTIVE Intrauterine infection increases proinflammatory cytokines in the fetus. We hypothesize that proinflammatory cytokines and matrix metalloproteinases (MMPs) are upregulated in fetal hearts in response to hypoxic stress. STUDY DESIGN Timed-pregnant guinea pigs were exposed to either hypoxia (10.5% O(2), 14 day) or normoxia (room air). Left ventricles of fetal hearts were excised from anesthetized age-matched fetuses and frozen until ready for study. Messenger RNA of pro- (TNF-alpha… CONTINUE READING

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