Intrauterine growth retardation as an endpoint in mutation epidemiology: an evaluation based on paternal age.

@article{Olshan1995IntrauterineGR,
  title={Intrauterine growth retardation as an endpoint in mutation epidemiology: an evaluation based on paternal age.},
  author={Andrew F. Olshan and Cande V Ananth and David A. Savitz},
  journal={Mutation research},
  year={1995},
  volume={344 1-2},
  pages={89-94}
}
Czeizel recently suggested that intrauterine growth retardation might be of value as a phenotypic endpoint in mutation epidemiology. We hypothesized that if some fraction of small-for-gestational age (SGA) births are due to new germinal mutations, then an association with advanced paternal age should be present. We evaluated the relation between paternal age and SGA, low birthweight, and preterm births using a large sample of births (n = 254,892) from North Carolina. The analyses were… CONTINUE READING

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