Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling.

@article{Laviola2005IntrauterineGR,
  title={Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling.},
  author={Luigi Laviola and Sebastio Perrini and Gaetana Belsanti and Annalisa Natalicchio and Carmela Montrone and Anna Leonardini and Antonella Vimercati and Marco Scioscia and Luigi Selvaggi and Riccardo Giorgino and Pantaleo Greco and Francesco Giorgino},
  journal={Endocrinology},
  year={2005},
  volume={146 3},
  pages={1498-505}
}
The IGFs promote the growth and development of the feto-placental unit during gestation, and impairment of their placental actions may result in altered intrauterine growth of the fetus. In this study, proteins involved in IGF signaling were investigated in human placentas from pregnancies complicated by intrauterine growth restriction (IUGR) compared with those from normal pregnancies. IUGR placentas exhibited 33% reduction in the protein content of IGF-I receptors, but no changes in insulin… CONTINUE READING
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