Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep.

@article{Bubb2007IntrauterineGR,
  title={Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep.},
  author={Kristen J Bubb and Megan L Cock and M Jane Black and Miodrag Dodic and W. J. V. Van der Boon and Helena C Parkington and Richard Harding and Marianne Tare},
  journal={The Journal of physiology},
  year={2007},
  volume={578 Pt 3},
  pages={871-81}
}
There is now extensive evidence suggesting that intrauterine perturbations are linked with an increased risk of developing cardiovascular disease. Human epidemiological studies, supported by animal models, have demonstrated an association between low birth weight, a marker of intrauterine growth restriction (IUGR), and adult cardiovascular disease. However, little is known of the early influence of IUGR on the fetal heart and vessels. The aim of this study was to determine the effects of late… CONTINUE READING

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Restriction of placental function alters heart development in the sheep fetus.

American journal of physiology. Regulatory, integrative and comparative physiology • 2007
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