Intrauterine food restriction as a determinant of nephrosclerosis.

  title={Intrauterine food restriction as a determinant of nephrosclerosis.},
  author={Sofia Regina and Rudolf Lucas and Sandra Maria Miraglia and F Zaladek Gil and T Machado Coimbra},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={37 3},
We previously showed that 3-month-old rats subjected to a 50% intrauterine food restriction had a decreased number of nephrons with increased glomerular diameter, which suggests compensatory hypertrophy. Hypertrophy could be the early event of glomerular damage. In this study, we extended our investigation and performed functional, morphological, and immunohistochemical evaluations in 3- and 18-month-old rats that underwent a 50% intrauterine food restriction (RT3 and RT18, respectively) and… CONTINUE READING
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