Intrauterine exposure to diethylstilbestrol: long-term effects in humans.

  title={Intrauterine exposure to diethylstilbestrol: long-term effects in humans.},
  author={Shanna Helen Swan},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={108 12},
DES is the most carefully scrutinized EDC and its history provides valuable insights into the current evaluation of less well-studied EDCs. This review summarizes the health effects of prenatal exposure to diethylstilbestrol (DES) and emphasizes the role of DES as the first endocrine disrupting chemical (EDC). Vaginal clear cell adenocarcinoma (CCAC), the most severe consequence of prenatal exposure to DES, affected only 0.1% of exposed females, while the far more prevalent teratogenic and… CONTINUE READING