Intrauterine environment and polycystic ovary syndrome.

  title={Intrauterine environment and polycystic ovary syndrome.},
  author={Daniel A Dumesic and Mark O Goodarzi and Gregorio D Chazenbalk and David H. Abbott},
  journal={Seminars in reproductive medicine},
  volume={32 3},
The maternal-fetal environment plays an important role in developmental programming of adult disease. Metabolic and hormonal dysfunction during human fetal development accompanies gestational diabetes as a common occurrence in mothers with polycystic ovary syndrome (PCOS), while human fetal androgen excess from congenital adrenal hyperplasia or virilizing tumors precedes PCOS-like symptoms after birth. To date, clinical studies of infant blood levels at term have yet to confirm that human fetal… CONTINUE READING


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