Intrauterine Growth Retardation Alters Mitochondrial Gene Expression and Function in Fetal and Juvenile Rat Skeletal Muscle

@article{Lane1998IntrauterineGR,
  title={Intrauterine Growth Retardation Alters Mitochondrial Gene Expression and Function in Fetal and Juvenile Rat Skeletal Muscle},
  author={Robert Hooijberg Nancy Lane and Aarti K Chandorkar and Annette S. Flozak and Rebecca A. Simmons},
  journal={Pediatric Research},
  year={1998},
  volume={43},
  pages={563-570}
}
Uteroplacental insufficiency alters the anabolic metabolism of the fetus, resulting in intrauterine growth retardation (IUGR). The metabolic and physiologic factors that cause IUGR have long standing consequences after birth. Postnatal growth and glucose metabolism are altered in the IUGR infant. Skeletal muscle is an important component of growth and metabolizes up to 70% of i.v. glucose. The ability of skeletal muscle to metabolize glucose is affected by ATP availability. We hypothesized that… CONTINUE READING
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