Intrauterine Growth Restriction, Preeclampsia, and Intrauterine Mortality at High Altitude in Bolivia

@article{Keyes2003IntrauterineGR,
  title={Intrauterine Growth Restriction, Preeclampsia, and Intrauterine Mortality at High Altitude in Bolivia},
  author={Linda E Keyes and Fernando J Armaza and Susan Niermeyer and Enrique Vargas and David A Young and Lorna G. Moore},
  journal={Pediatric Research},
  year={2003},
  volume={54},
  pages={20-25}
}
Infant mortality and stillbirth rates in Bolivia are high and birth weights are low compared with other South American countries. Most Bolivians live at altitudes of 2500 m or higher. We sought to determine the impact of high altitude on the frequency of preeclampsia, gestational hypertension, and other pregnancy-related complications in Bolivia. We then asked whether increased preeclampsia and gestational hypertension at high altitude contributed to low birth weight and increased stillbirths… Expand

Paper Mentions

Observational Clinical Trial
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth… Expand
ConditionsIUGR, Preeclampsia, Pregnancy
InterventionProcedure
Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
  • L. Moore
  • Biology, Medicine
  • High altitude medicine & biology
  • 2003
TLDR
Pregnancy increases maternal ventilation and raises arterial O(2) saturation at high altitude, which helps to protect against altitude-associated IUGR. Expand
Fetal growth and spontaneous preterm birth in high-altitude pregnancy: A systematic review, meta-analysis, and meta-regression.
  • I. Grant, D. Giussani, C. Aiken
  • Medicine
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2021
TLDR
Globally, the likelihood of adverse perinatal outcomes, including LBW, SGA, and sPTB, increases in high-altitude pregnancies, and there is an inverse relationship between birth weight and altitude. Expand
[Effect of high altitude on birth weight and adverse perinatal outcomes in two Argentine populations].
TLDR
Altitude was independently associated with BW restriction and adverse perinatal outcomes in two argentine populations, given the impact of BW reduction in the risk of chronic no communicable diseases this relationship in other populations, regardless of their location altitude, should be assess. Expand
High-altitude ancestry protects against hypoxia-associated reductions in fetal growth
TLDR
The intermediate protection seen in the admixed (Mestizo) group is consistent with the influence of genetic or other Andean-specific protective characteristics. Expand
Parental ancestry and risk of early pregnancy loss at high altitude
  • I. Grant, R. Soria, +4 authors D. Giussani
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2020
TLDR
The risk of miscarriage at high altitude is lower in Andean women and the lack of a paternal ancestry effect suggests underlying mechanisms relate more to differential maternal adaptation in early pregnancy than fetal genetics. Expand
High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy.
  • B. Bailey, A. Euser, K. Bol, C. Julian, L. Moore
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2020
TLDR
Residence at high altitude constitutes a risk factor forHDP and recommends increased clinical surveillance, and the increased incidence makes high altitude a natural laboratory for evaluating the efficacy of predictive biomarkers or new therapies for HDP. Expand
Maternal exposure to low-to-medium altitude and birth outcomes: evidence from a population-based study in Chinese newborns
TLDR
The present results suggest that low-to-medium altitude is possibly associated with adverse birth outcomes, and generalized linear models were fitted to investigate the association of altitude with birth outcomes. Expand
Circulating fetal DNA in maternal plasma is increased in pregnancies at high altitude and is further enhanced by preeclampsia.
TLDR
Whether circulating fetal DNA concentrations are affected in pregnancies at high altitude is investigated because it has been reported that ethnic groups that have adapted to living at high altitudes for centuries or millennia have better pregnancy outcomes than recent migrants, e.g., native Tibetans. Expand
REPRODUCTIVE CHALLENGES AT HIGH ALTITUDE: fertility, pregnancy and neonatal well-being.
TLDR
The gene region containing PRKAA1 (coding for AMPK's alpha-1 catalytic subunit) has been acted upon by natural selection in Andeans and is related to preservation of normal blood flow and fetal growth at high altitude, suggesting one mechanism by which high-altitude adaptation may have been achieved. Expand
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