Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study

@article{Suckfuell2007IntratympanicTO,
  title={Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study},
  author={>M. Suckfuell and Martin Canis and Sebastian Strieth and Hans H. Scherer and Andreas Haisch},
  journal={Acta Oto-Laryngologica},
  year={2007},
  volume={127},
  pages={938 - 942}
}
Objectives. Intratympanic administration of a cell-permeable JNK ligand has been shown to prevent hearing loss after acute acoustic trauma in animal models. Conclusions. Functional and morphological analysis of the treated ears revealed that AM-111 had an excellent otoprotective effect, even when administered hours after the noise exposure. Blocking the signal pathway with D-JNKI-1 is therefore a promising way to protect the morphological integrity and physiological function of the inner ear in… 
Protection Against Ischemic Cochlear Damage by Intratympanic Administration of AM-111
TLDR
Direct application of AM-111 in gel formulation on the round window was effective in preventing acute hearing loss because of transient cochlear ischemia.
Zur Rolle der Mikrozirkulation in der Pathophysiologie der Cochlea
TLDR
Betahistine most likely affects cochlear blood flow through histaminergic H 3 -heteroreceptors through acting as an agonist at the histamine H 1 -receptor and as an inverse agonists at the H 3-receptor.
Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss: A Double-Blind, Randomized, Placebo-Controlled Phase II Study
  • M. SuckfuellG. Lisowska Thomas Meyer
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2014
TLDR
In severe-to-profound ASNHL patients (threshold ≥60 dB), AM-111 showed statistically significant, clinically relevant, and persistent improvements in hearing and speech discrimination and higher tinnitus remission compared with placebo.
Intracochlear drug delivery systems: a novel approach whose time has come
TLDR
For safe and efficacious inner ear administration, precisely controlled, programmable and chronic delivery systems may be required and design and development of these systems have leveraged rapid advances in microfabrication and microfluidics technologies toward platforms suitable for preclinical and clinical use.
Otoprotectants: From Research to Clinical Application.
TLDR
There is an urgent need for otoprotective drug agents for the purpose of protecting the inner ear against damage, and preventing associated hearing loss (otoprotection).
Adenosine Amine Congener as a Cochlear Rescue Agent
TLDR
The data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment.
Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise
TLDR
The review will discuss noise-induced cochlear pathology, including alterations to the blood-labyrinth barrier, and then transition into discussing approaches for delivery of oto-protective compounds to reduce co chlear injury from noise.
[Intracochlear drug delivery in combination with cochlear implants : Current aspects].
TLDR
Two CI-wearing patients successfully underwent intracochlear placement of a biocompatible, resorbable drug delivery system for controlled release of dexamethasone, and the drug levels reached in inner ear fluids after different types of local drug application strategies can be calculated using computer models.
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Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feuerwerkskörper. Für die Einschätzung der gesundheitlichen und gesundheitspolitischen Bedeutung, für die Beratung
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