Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study

  title={Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study},
  author={>M. Suckfuell and Martin Canis and Sebastian Strieth and Hans H. Scherer and Andreas Haisch},
  journal={Acta Oto-Laryngologica},
  pages={938 - 942}
Objectives. Intratympanic administration of a cell-permeable JNK ligand has been shown to prevent hearing loss after acute acoustic trauma in animal models. Conclusions. Functional and morphological analysis of the treated ears revealed that AM-111 had an excellent otoprotective effect, even when administered hours after the noise exposure. Blocking the signal pathway with D-JNKI-1 is therefore a promising way to protect the morphological integrity and physiological function of the inner ear in… 
Protection Against Ischemic Cochlear Damage by Intratympanic Administration of AM-111
Direct application of AM-111 in gel formulation on the round window was effective in preventing acute hearing loss because of transient cochlear ischemia.
Zur Rolle der Mikrozirkulation in der Pathophysiologie der Cochlea
Betahistine most likely affects cochlear blood flow through histaminergic H 3 -heteroreceptors through acting as an agonist at the histamine H 1 -receptor and as an inverse agonists at the H 3-receptor.
Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss: A Double-Blind, Randomized, Placebo-Controlled Phase II Study
  • M. SuckfuellG. Lisowska Thomas Meyer
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2014
In severe-to-profound ASNHL patients (threshold ≥60 dB), AM-111 showed statistically significant, clinically relevant, and persistent improvements in hearing and speech discrimination and higher tinnitus remission compared with placebo.
Intracochlear drug delivery systems: a novel approach whose time has come
For safe and efficacious inner ear administration, precisely controlled, programmable and chronic delivery systems may be required and design and development of these systems have leveraged rapid advances in microfabrication and microfluidics technologies toward platforms suitable for preclinical and clinical use.
Otoprotectants: From Research to Clinical Application.
There is an urgent need for otoprotective drug agents for the purpose of protecting the inner ear against damage, and preventing associated hearing loss (otoprotection).
Adenosine Amine Congener as a Cochlear Rescue Agent
The data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment.
Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise
The review will discuss noise-induced cochlear pathology, including alterations to the blood-labyrinth barrier, and then transition into discussing approaches for delivery of oto-protective compounds to reduce co chlear injury from noise.
[Intracochlear drug delivery in combination with cochlear implants : Current aspects].
Two CI-wearing patients successfully underwent intracochlear placement of a biocompatible, resorbable drug delivery system for controlled release of dexamethasone, and the drug levels reached in inner ear fluids after different types of local drug application strategies can be calculated using computer models.


Excitotoxicity and repair of cochlear synapses after noise‐trauma induced hearing loss
The high degree of protection observed with kynurenate attests that dendritic damage is an important component in noise-induced hearing loss and demonstrates that a synaptic repair mechanism occurring within the first few days post-exposure is partly responsible for the recovery of temporary threshold shifts after an acoustic trauma.
Acoustic trauma causes reversible stiffness changes in auditory sensory cells
Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation
The results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries.
The Caspase Pathway in Noise-Induced Apoptosis of the Chinchilla Cochlea
The results indicate that multiple signaling pathways leading to caspase-3 activation take place simultaneously in the apoptotic OHCs, and suggest that in this subpopulation there exists a common step that is shared by cell death pathways before entering either necrosis or apoptosis.
Temporary and permanent threshold shift: an overview.
Temporary threshold shift as well as permanent threshold shift represent the most common hearing effect of acute and chronic high level acoustic stimulation, usually accompanied with alterations of several cochlear functions leading to altered speech discrimination mostly in presence of background noise.
Impulse noise: critical review.
A review of the last 10 years of research on impulse noise reveals certain insights and perspectives on the biological and audiological effects of exposures to impulse noise. First, impulse noise may
Erholung der Hörschwelle nach Knalltrauma durch Feuerwerkskörper und Signalpistolen
Mehrere Tausend Menschen erleiden jedes Jahr ein Knall- oder Explosionstrauma durch Feuerwerkskörper. Für die Einschätzung der gesundheitlichen und gesundheitspolitischen Bedeutung, für die Beratung