Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications.

  title={Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications.},
  author={Marco Gerlinger and James W. F. Catto and Torben Falck Orntoft and Francisco X Real and Ellen C. Zwarthoff and Charles Swanton},
  journal={European urology},
  volume={67 4},
CONTEXT Intratumour heterogeneity (ITH) can impair the precise molecular analysis of tumours and may contribute to difficulties encountered in cancer biomarker qualification and treatment personalisation. OBJECTIVE This review summarises the evidence for genetic ITH in renal, bladder, and prostate carcinomas and potential strategies to address the clinical and translational research challenges arising from ITH. EVIDENCE ACQUISITION Publications that assessed ITH in the relevant urologic… CONTINUE READING
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