Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients

@inproceedings{Jie2013IntratumoralRT,
  title={Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients},
  author={H-B Jie and Neil Gildener-Leapman and Junmin Li and Raghvendra M. Srivastava and Sandra Poveda Gibson and Theresa L Whiteside and Robert L Ferris},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:Although regulatory T cells (Treg) are highly enriched in human tumours compared with peripheral blood, expression of the immune-checkpoint receptors, immunosuppressive molecules and function of Treg in these two sites remains undefined.Methods:Tumour-infiltrating lymphocytes and peripheral blood lymphocytes were isolated from a cohort of head and neck squamous cell carcinoma (HNSCC) patients. The immunosuppressive phenotypes and function of intratumoral Treg were compared with those… CONTINUE READING