Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma

Abstract

Seven immunocompetent, revaccinated patients with surgically incurable cutaneous melanoma underwent treatment of dermal and/or subcutaneous metastases with twice-weekly intratumoral injections of escalating doses (104−2 × 107 plaque-forming units (PFU)/lesion; 104−8 × 107 PFU/session) of a vaccinia/GM-CSF recombinant virus for 6 weeks. Patients with stable… (More)
DOI: 10.1038/sj.cgt.7700066

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@article{Mastrangelo1999IntratumoralRG, title={Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma}, author={Michael J. Mastrangelo and Henry C. Maguire and Laurence C. Eisenlohr and Carol E. Laughlin and Claude E. Monken and Peter A. McCue and Albert J. Kovatich and Edmund C. Lattime}, journal={Cancer Gene Therapy}, year={1999}, volume={6}, pages={409-422} }