Intratumoral radioimmunotherapy of a human colon cancer xenograft using a sustained-release gel.

@article{Ning1996IntratumoralRO,
  title={Intratumoral radioimmunotherapy of a human colon cancer xenograft using a sustained-release gel.},
  author={Shoucheng Ning and Kirk Trisler and Dennis M.D Brown and Ning Y. Yu and Sarathchandra Kanekal and M J Lundsten and Susan J. Knox},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1996},
  volume={39 2},
  pages={
          179-89
        }
}
Low tumor uptake and normal tissue toxicity limit the efficacy of RIT for the treatment of solid tumors. In this study, an intratumoral injectable gel drug delivery system for local administration of RIT was evaluated using the LS174T human colon cancer xenograft model in SCID mice. The injectable gel is a collagen-based drug delivery system designed for intratumoral (i.t.) administration, which has previously been shown to enhance drug retention at the injection site and reduce systemic drug… CONTINUE READING
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