Intratumoral lymphangiogenesis in oral squamous cell carcinoma and its clinicopathological significance.

@article{Zhao2008IntratumoralLI,
  title={Intratumoral lymphangiogenesis in oral squamous cell carcinoma and its clinicopathological significance.},
  author={Damin Zhao and Jian Pan and Xiao Qiang Li and Xiao Wang and Chunhui Tang and Ming Xuan},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2008},
  volume={37 10},
  pages={616-25}
}
Lymphatic metastasis has always been regarded as a major prognostic indicator for disease progression and as a guide for therapeutic strategies to oral squamous cell carcinoma (OSCC), but to date, how tumor cells access and spread via the lymphatics have not been fully elucidated. Whether tumor cells metastasize by expansion and invasion of pre-existing peritumoral lymphatics or by the induction and invasion of newly formed lymphatics within tumors is controversial. In order to address this… CONTINUE READING

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