Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

  title={Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses},
  author={Nicholas John Roberts and Linping Zhang and Filip Janku and Amanda Collins and R Bai and Verena Staedtke and Anthony W. Rusk and David J. Tung and Maria Miller and Jeffrey J. Roix and Kristen V. Khanna and Ravi Murthy and Robert S Benjamin and Thorunn Helgason and Ariel D Szvalb and Justin E. Bird and Sinchita Roy-Chowdhuri and Halle Huihong Zhang and Yuan Qiao and Baktiar O. Karim and Jennifer S. McDaniel and Amanda Elpiner and Alexandra I Sahora and Joshua Lachowicz and Brenda R. Phillips and Avenelle Turner and Mary Kay Klein and Gerald Post and Luis A Diaz and Gregory Joseph Riggins and Nickolas Papadopoulos and Kenneth W. Kinzler and Bert Vogelstein and C Bettegowda and David Leonard Huso and Mary Varterasian and Saurabh Saha and Shibin Zhou},
  journal={Science Translational Medicine},
Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral injection. It is well known, however, that experimental models often do not reliably predict the responses of human patients to therapeutic agents. We therefore used naturally occurring canine… CONTINUE READING
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